Yeni İki Hetero halkalı Bir Yapı Olarak Tiyoüreyle Kaynaşmış Furazan Sentezi ve Biyolojik Değerlendirmesi

A new imidazole-2-thione fused furazan biheterocyclic group was synthesized and its biological activity investigated. Nitrogen rich heterocycles, 1,2,5-oxadiazole (furazan) have been conveni ently fused. To accomplish this, we improved a strategy that silica gel supported solvent free micro wave dehydration of vicinal dioximes. The target "N,N’-diphenyl-4H-imidazo[4,5-c]furazan-5(6H) –thio ne" [II] (DFTFrz) obtained from (4E,5Z)-4,5-bis(hydroxyimino)-N,N’-diphenylimidazolidine-2-thione [I] (DFTD) with acceptable yield characterized by LC-MS/MS, FT-IR NMR spectroscopy. evaluation the thiourea precursor dioxime were investigated antibacterial effect studies using broth microdilution disc diffusion methods. It observed thioure more effective on tested pathogenic bacteria than dioxime. compounds did not show any gram negative bacteria, while they exhibited moderate positive especially Staphylococcus spp.